Meghan Markle urged young teens to "challenge injustice" to help "define a path forward" during a virtual talk.
The Duchess of Sussex held a roundtable with 13 to 18-year-olds and spoke to them about their "everyday struggles" during the pandemic.
She was joined by the leaders of Girls Inc and The National Women's Law Centre, both of which advocate for women's legal rights.
Struggles the girls have faced include mental health, racism and "identity loss and isolation."
A post on Prince Harry and Meghan Markle's Archewell website said the women in the group all have big ambitions of being medical professionals, senators and presidents.
The statement reads: "As young activists, these girls are already making an impact around education, social justice, and health and wellness in their own schools and communities.'
"The girls who attended had strong and incisive perspectives on issues critical to girls today."
Meghan also asked the girls to share their female role models who "embolden them to challenge injustice."
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Over the last year, Meghan has met with several organisations and spearheaded conversations with women and girls.
She has advocated for a more "just future" without inequality and institutional racism.
Her recent show of activism comes after Harry and Meghan sat down with Oprah Winfrey to speak of life within the Firm.
Both Harry and Meghan spoke of their struggles with mental health within the Royal Family, with the Duke of Sussex claiming that he felt "trapped."
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The Duchess of Sussex also sensationally claimed a senior Royal approached Harry about the colour of their son's skin prior to his birth.
Meghan and Harry's claims shocked the world, and Buckingham Palace was forced to issue a statement in response.
The Palace said: "The whole family is saddened to learn the full extent of how challenging the last few years have been for Harry and Meghan.
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"The issues raised, particularly that of race, are concerning. While some recollections may vary, they are taken very seriously and will be addressed by the family privately.
"Harry, Meghan and Archie will always be much-loved family members."
Meghan also claimed that she had been refused help after revealing she had been suffering from suicidal thoughts.
For emotional support, you can call the Samaritans 24-hour helpline on 116 123, email [email protected], visit a Samaritans branch in person or go to the Samaritans website.
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